Effect of mineralocorticoid replacement therapy on renal acid-base homeostasis in adrenalectomized patients

Renal Physiology Acid-Base Homeostasis

Acid-base homeostasis and pH regulation are critical for both normal physiology and cell metabolism and function. The importance of this regulation is evidenced by a variety of physiologic derangements that occur when plasma pH is either high or low. The kidneys have the predominant role in regulating the systemic bicarbonate concentration and hence, the metabolic component of acid-base balance...

Effect of growth hormone on renal and systemic acid-base homeostasis in humans.

The effects of recombinant human growth hormone (GH, 0.1 U ⋅ kg body wt-1 ⋅ 12 h-1) on systemic and renal acid-base homeostasis were investigated in six normal subjects with preexisting sustained chronic metabolic acidosis, induced by NH4Cl administration (4.2 mmol ⋅ kg body wt-1 ⋅ day-1). GH administration increased and maintained plasma bicarbonate concentration from 14.1 ± 1.4 to 18.6 ± 1.1 ...

REGULATION OF ACID-BASE HOMEOSTASIS BY THE KIDNEY

Renal mineralocorticoid receptor and electrolyte homeostasis.

The renal mineralocorticoid receptor (MR) is a steroid hormone receptor essential for maintaining electrolyte homeostasis. Its role in mediating effects of aldosterone was likely vital in enabling the evolution of terrestrial life. Dysregulated aldosterone-MR signaling has been identified as the cause of multiple clinical diseases, suggesting the physiological importance of the MR. While the ph...

The Effect of Iron Replacement Therapy on Electrocardiographic Consequences in Pediatric Patients

Background Sudden cardiac death is an important problem, because the patients have no opportunity to receive medical service. Recently some electrocardiogram (ECG) parameters are used for predicting arrhythmias, including P wave duration for predicting atrial arrhythmias and corrected QT and T wave peak to end interval (Tp-e), for predicting ventricular arrhythmi...